陈依璠,邢平川,朱诗源,雷涛,周建芝,王志军

• 1:华北理工大学研究生学院
• 2:华北理工大学附属医院心血管内科
• 3:华北理工大学校医院内科

摘要(Abstract)：

目的:探讨中性粒细胞百分比与白蛋白比值(neutrophil percentage to albumin ratio, NPAR)累积暴露与新发动脉硬化的关系。方法:采用队列研究设计，选取开滦研究队列中至少参加两次臂踝脉搏波检测并首次臂踝脉搏波检测前至少完成两次健康体检者作为研究对象，最终符合入选标准的共15 446例。将研究对象按时间加权平均值计算的NPAR累积暴露水平四分位数分成Q1组(NPAR≤11.36)、Q2组(11.3613.68),采用泊松回归分析及敏感性分析探讨NPAR累积暴露与新发动脉硬化的关系。结果:Q1～Q4组分别有研究对象3 861例、3 862例、3 862例、3 861例。随着NPAR累积暴露水平升高，4组的年龄、服用降压药物者、糖尿病人数、超敏C反应蛋白、空腹血糖呈现递增趋势，除空腹血糖外，余P<0.05具有统计学意义。泊松回归分析表明，调整其他混杂因素后，Q2～Q4组与Q1组相比均是新发动脉硬化发生的独立危险因素，且与Q1组相比，最高暴露Q4组新发动脉硬化的风险高出19%[相对风险(RR)=1.19,95%置信区间(CI):1.03～1.36,P<0.05]。敏感性分析验证了结果的稳定性。结论:高水平NPAR累积暴露是新发动脉硬化发生的独立危险因素。

关键词(KeyWords)： 中性粒细胞;白蛋白;累积暴露;动脉硬化

Abstract:

Keywords:

基金项目(Foundation): 2024年政府资助临床医学优秀人才培养项目（No:ZF2024198）

作者(Author): 陈依璠,邢平川,朱诗源,雷涛,周建芝,王志军

DOI: 10.13201/j.issn.1001-1439.2026.10.010

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